Diseases - all described below - include. A variety of hereditary causes are recognised including spinal muscular atrophy distal hereditary motor neuropathy and LMN variants of. Upper Motor Neuron Vs Lower Motor Neuron Google Search Physical Therapy Student Speech Language Therapy Speech Language Pathology Damage to lower motor neurons also entails a loss of muscle tone since tone is in part dependent on the monosynaptic reflex arc that links the muscle spindles to the lower motor neurons see also. . Spinal muscular atrophy SMA. The ability to examine a patient and determine where in the body the disease is located is critical to determining the cause best therapy and prognosis. A small proportion of ALS presents as an LMN monomelic disease albeit in an older patient population. The LMN NMJ and skeletal muscle fibers together make up the motor unit. Among the 27 cases seven had UMN signs and LMN signs as well as parkinsoni
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